Clinical significance of serum lactate dehydrogenase, phosphohexose isomerase, aldolase and hexokinase in prostatic carcinoma.
نویسنده
چکیده
The enzyme activities of Lactate dehydrogenase (LDH). prostate fluid LDH isoenzymes phosphohexose isomerase (PHI), Aldolase (ALD) and Hexokinase (HK) were determined in the sera of 77 samples of males. There were 12 cases of carcinoma prostate with metastases, 15 without metastases, 25 with benign prostatic hypertrophy and 25 nontumor. The enzyme activities of nontumor and benign group were statistically similar. The prostatic fluid LDH5/LDH1 ratio and PHI has been found to be the most sensitive parameter for detecting carcinoma prostate. Serial determinations of LDH, PHI, ALD and HK were found valuable for following the course of the disease during therapy.
منابع مشابه
Significance of serum phosphohexose isomerase, hexokinase and aldolase in carcinoma ovary.
The serum phosphohexose isomerase (PHI), aldolase and hexokinase activities have been determined in 36 patients of carcinoma ovary with different clinical stages and in 25 healthy normal female subjects. The serum PHI and hexokinase levels were significantly elevated (P less than .001) in all the stages of malignancy while serum aldolase was significantly elevated only in stages III and IV of m...
متن کاملVaginal fluid enzyme patterns in benign and malignant lesions of the female genital tract.
The enzymes phosphohexose isomerase, lactate dehydrogenase, hydroxybutyrate dehydrogenase, isocitric dehydrogenase, glutamate dehydrogenase, and sorbital dehydrogenase were assayed in cases of known carcinoma of the cervix and of carcinoma in situ. Phosphohexose isomerase, lactate dehydrogenase, and isocitric dehydrogenase were also assayed in a number of normal women and in those with benign l...
متن کاملCopper-resistant serum acid phosphatase. I. Method and values in health and disease.
Human serum contains a mixture of phosphomonoesterases derived from several types of cells with optimum activity at pH 5.0. Clinical assay methods in current use have been developed pri marii}7 to measure acid phosphatases of prostatic origin in metastatic prostatic cancer (10, 11, 15, 30, 34), although increased serum acid phosphatase activity has been noted in patients with neo plasms dissemi...
متن کاملActivities and isoenzyme patterns of some enzymes of glucose metabolism in human primary malignant hepatoma.
The levels of a number of enzymes of carbohydrate metabolism were assayed in the cancerous and morphologically normal (host) portions of livers from nine primary malignant hepatoma cases obtained at autopsy. The levels of these enzymes in two normal human adult and two fetal livers were also determined. The activities of phosphoglucomutase, fructose 1,6-diphosphatase and a-glycerophosphate dehy...
متن کاملATP: creatine phosphotransferase in the diagnosis of acute chest pain.
A common problem in clinical medicine is the diagnosis of acute chest pain. Usually, the history, clinical findings, and electrocardiographic evidence are sufficient to enable the clinician to reach a confident diagnosis. Some cases, however, have atypical features or show an electrocardiogram difficult of interpretation, because of previous infarction, left bundle-branch block, previous left v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Indian journal of physiology and pharmacology
دوره 29 1 شماره
صفحات -
تاریخ انتشار 1985